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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN2
All Species:
30
Human Site:
T261
Identified Species:
60
UniProt:
P17706
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17706
NP_002819.1
415
48473
T261
Y
R
M
G
L
I
Q
T
P
D
Q
L
R
F
S
Chimpanzee
Pan troglodytes
XP_512196
415
48479
T261
Y
R
M
G
L
I
Q
T
P
D
Q
L
R
F
S
Rhesus Macaque
Macaca mulatta
XP_001118328
448
50818
D301
L
V
L
M
E
K
G
D
D
I
N
I
K
Q
V
Dog
Lupus familis
XP_547685
388
45298
I243
L
M
E
K
G
D
D
I
N
I
K
Q
L
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q06180
406
47342
T261
Y
R
M
G
L
I
Q
T
P
D
Q
L
R
F
S
Rat
Rattus norvegicus
P35233
363
42217
A218
P
A
V
I
H
C
S
A
G
I
G
R
S
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508429
545
61767
T265
Y
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Chicken
Gallus gallus
O13016
434
50316
T263
Y
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Frog
Xenopus laevis
NP_001086910
468
54192
T261
Y
R
M
G
L
I
Q
T
P
G
Q
L
R
F
S
Zebra Danio
Brachydanio rerio
NP_997819
393
45640
L248
L
V
D
I
K
K
I
L
L
D
M
R
K
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W0G1
548
62086
T282
Y
R
M
G
L
I
Q
T
A
D
Q
L
D
F
S
Honey Bee
Apis mellifera
XP_392429
495
55903
T277
S
R
M
G
L
I
Q
T
P
D
Q
L
R
F
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
69.1
86.9
N.A.
88.6
79.7
N.A.
41.4
53
54.2
57.5
N.A.
31.9
40.2
N.A.
N.A.
Protein Similarity:
100
99.7
75.8
88.9
N.A.
92.5
84
N.A.
53.2
70
67
71.5
N.A.
46.9
55.5
N.A.
N.A.
P-Site Identity:
100
100
0
0
N.A.
100
0
N.A.
93.3
93.3
93.3
6.6
N.A.
86.6
93.3
N.A.
N.A.
P-Site Similarity:
100
100
20
6.6
N.A.
100
13.3
N.A.
93.3
93.3
93.3
20
N.A.
86.6
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
9
25
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
9
9
9
9
67
0
0
9
0
0
% D
% Glu:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% F
% Gly:
0
0
0
67
9
0
9
0
9
9
9
0
0
9
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
17
0
67
9
9
0
25
0
9
0
0
0
% I
% Lys:
0
0
0
9
9
17
0
0
0
0
9
0
17
0
0
% K
% Leu:
25
0
9
0
67
0
0
9
9
0
0
67
9
9
9
% L
% Met:
0
9
67
9
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% N
% Pro:
9
0
0
0
0
0
0
0
42
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
67
0
0
0
67
9
0
9
0
% Q
% Arg:
0
67
0
0
0
0
0
0
0
0
0
17
59
0
9
% R
% Ser:
9
0
0
0
0
0
9
0
0
0
0
0
9
0
67
% S
% Thr:
0
0
0
0
0
0
0
67
0
0
0
0
0
0
9
% T
% Val:
0
17
9
0
0
0
0
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
59
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _